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KMID : 0616120090400030233
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 3 p.233 ~ p.237
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Inhibitory Effects of Water Extract of Lindera obtusiloba on the Mast Cell-Mediated Allergic Inflammation
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Kim Sang-Hyun
Son Jun-Ho
Lee Seung-Ho
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Abstract
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Lindera obtusiloba has been used for centuries as a traditional medicine in Korea and recently known to have an anti-fibrotic effect. In this report, we investigated the effect of hot water extract from L. obtusiloba (WELB) on the mast cell-mediated allergic inflammation and studied its possible mechanisms of action. WELB inhibited phorbol-12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced histamine release in HMC-1 human mast cells. WELB reduced PMACI-induced gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-8. The inhibitory effect of WELB on the expression of proinflammatory cytokines was c-jun N-terminal kinase and nuclear factor-κB dependent. These results indicate that WELB may be beneficial in the treatment of mast cell-mediated allergic inflammation.
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KEYWORD
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Lindera obtusiloba, histamine, proinflammatory cytokine, mast cells, allergic inflammation
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